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Entre os dias 29 de junho a 3 de julho, em Brasília, acontece o curso de Toxicologia Regulatória, realizado pelo Swiss Centre for Applied Human Toxicology, da Universidade de Basel, da Suíça. As aulas serão ministradas apenas em inglês

O curso tem o objetivo de fornecer uma ampla compreensão da toxicologia reguladora na área de agroquímicos. Nele será abordada uma introdução aos conceitos básicos de avaliação do risco regulatório, bem como do perigo e os princípios da exposição.

“É importante ressaltar que o curso é direcionado para aqueles que já possuem um conhecimento aprofundado sobre os conceitos toxicológicos”, enfatiza Guilherme Guimarães, gerente Técnico e de Regulamentação Federal da Andef.

O custo do curso é de US$ 2,000.00 (dois mil dólares), incluindo todos os materiais. Para se inscrever, envie um e-mail para fabiana@andef.com.br ou entre em contato (11) 3087-5033. As vagas são limitadas.

Confira a programação na íntegra: 

DAY 1: Risk assessment processes 
09:00 – 09:45The risk assessment paradigm
09:45 – 10.30Hazard identification incl. GHS
10:30 – 11:00Coffee
11:00 – 11:45Hazard characterization
OECD Test Guideline Programme (TGP)
11:45 – 12.30Exposure assessment & risk characterization
12:30 – 14:30Lunch
14:30 – 15:15Mutagenic substances – regulatory approaches 
Test systems 
Classification and labeling
15:15 – 16:00Carcinogenic substances – regulatory approaches 
Test systems 
Classification and labeling 
Hazard driven versus risk driven risk assessment approaches
Non-threshold versus threshold effects; Mutagenic versus non-mutagenic carcinogens; tumour initiation, tumor promotion
16:00 – 16:30Coffee
16:30 – 17:15Substances toxic to Reproduction 
PART I: Developmental toxicity
17:15 – 18:00Substances toxic to Reproduction 
PART II: Fertility
 
DAY 2: Hazard of PPPs in the context of most relevant organ toxicity 
09:00 – 09:45Endocrine Disrupting Compounds (EDCs), PART I: Regulatory approaches, EATS
09:45 – 10.30Endocrine Disrupting Compounds (EDCs), PART II: Mechanistic approaches
E.g. case study on prioritizing chemicals for evaluation of endocrine disrupting potential (US EPA EDSP, conazole pharma vs. agchem, atrazine?, …)
10:30 – 11:00Coffee
11:00 – 11:45Neurotoxicity
PART I: Insecticides, substance classes and targets
11:45 – 12.30Developmental Neurotoxicity (Driver: FQPA – extra 10x safety factor for protection of children)
PART II: Case study neonicotinoids [EFSA review, Paper Anna Price]
12:30 – 14:30Lunch
14:30 – 15:15Organ toxicity, PART I: liver, kidney
15:15 – 16:00Organ toxicity, PART II: skin irritation & sensitization, immunotoxicity
16:00 – 16:30Coffee
16:30 – 17:15Species concordance: Pharmacokinetics / Pharmacodynamics, PART I
17:15 – 18:00Species concordance: Pharmacokinetics / Pharmacodynamics, PART II
E.g. case study on lack of human concordance: rodent specific PPAR-mediated non-mutagenic hepatocarcinogenicity.  (PPAR: Peroxisome Proliferator-Activated Receptor) 
E.g. case study on lack of human concordance: E.g. species and sex-specific kidney tumors in male rats through binding to a male rat specific protein (alpha-2u-globulin).
E.g. case study on the use of kinetic data in species concordance analysis and implications for dose response analysis: E.g. cacodylic acid induced dose related increase in the incidence in bladder tumors in rats but not in mice.
Examples from IPCS – MoA, human relevance framework (PPAR liver ca +)
 
DAY 3: Exposure assessment of PPPs (external to Uni Basel) 
09:00 – 09:45Operator exposure (OPEX and re-entry) = 6 hours 
Exposure scenarios and exposure modeling
09:45 – 10.30Exposure scenarios and exposure modelling continued
10:30 – 11:00Coffee
11:00 – 11:45Field studies, Personal protective equipment (PPE)
11:45 – 12.30Worker exposure
12:30 – 14:30Lunch
14:30 – 15:15Worker exposure continued
15:15 – 16:00Consumer exposure incl. Codex Alimentarius
Residues and consumer safety
16:00 – 16:30Coffee
16:30 – 17:15Consumer exposure
Residues and consumer safety continued
17:15 – 18:00Residues and consumer safety continued
 
DAY 4: Current issues – Paradigm shift – Understanding toxicity pathways and targeted testing
09:00 – 09:45PART I: Compounds
Risk assessment of mixtures / cumulative risk assessment 
Approaches for Evaluating Combined Health Effects from Exposure to Multiple Environmental Stressors NIH, 2012, WHO
 
09:45 – 10.30PART I: Compounds continued
Risk assessment of mixtures / cumulative risk assessment 
Case study: OPs – USA
Case study: conazoles – EU
10:30 – 11:00Coffee
11:00 – 12:00PART II: Non monotonic dose response – opinions of regulatory bodies
Implications of Non monotonic dose response curves (NMDRs) for current testing and assessment 
US EPA; jrc.ec.europa; Industry association
Case studies: BPA paper (RF & MW), EFSA on BPA – Vandenberg; Anna Price (nicotinic DNT), Vinclozolin (BASF 2010)
12:00 – 14:00Lunch
14:30 – 15:15PART III: Systems
TOX 21 – Drivers for change
MW ppt at SGPT 2014
15:15 – 16:00PART IV: Frameworks and implementation 
WHO: International Programme on Chemical Safety (IPCS) = MoA
16:00 – 16:30Coffee
16:30 – 17:15PART IV: Frameworks and implementation continued
OECD Adverse Outcome Programme (AOP)
17:15 – 18:00PART IV: Frameworks and implementation continued
Integrated Testing Strategies (ITS); OECD Integrated Approach on Testing and Assessment (IATA)
 
DAY 5: Current issues – Paradigm shift – Understanding toxicity pathways and targeted testing
09:00 – 09:45Human bio-monitoring and biomarkers; Omics; Exposome
09:45 – 10.30“RISK 21” (ILSI / HESI) combining  “TOX 21” & exposure
10:30 – 11:00Coffee
11:00 – 11:45Risk management incl. risk-benefit and socio-economic analysis; USA vs. Europe (precautionary principle)
11:45 – 12.30Public risk perception and PPPs; risk communication
12:30 – 14:30Lunch
14:30 – 15:30Exam
15:30 – 16:00Wrap up
16:00 –  End
 

Serviço:

De 29 de junho a 3 de julho de 2015

Hotel Mercure Brasília Eixo – Brasília/DF

Fonte: Comunicação Andef, com informações do SCAHT

ANDEF. Avenida Roque Petroni Júnior, 850 . 19º andar . Torre Jaceru . Jardim das Acácias . CEP: 04707-000 . Tel.: 55 (11) 3087-5033 - (Mapa) Desenvolvido por UAU!LINE.